The only problem I see with a big block is the on going poor fuel economy. Let's face it, gas prices are only going to get worse. There is also the longevity thing, and as a rule, a gas engine isn't going to do the work of a diesel, last as long as a diesel, nor put out the power (torque) of a diesel, and continue doing so for a long time.
The change from gas to diesel is a one time expense, and the Cummins will simply out pull, out last, and and big block gas engine, and will give you better fuel economy while doing that.
I have 2 Cummins pickups, and have had a number of big block pick ups. When I changed for gas power to diesel power, I realized that I'd been doing it wrong all those years.
I just sold off a 2500 Cummins with 471,000 miles on it, and besides normal maintenance, the only repair that I had to do to the engine was 2 water pumps, and an A/C compressor. That's nearly a half million miles.
While we've all heard about someone who got big mileage out of a gas engine, the fact of the matter is the vast majority of gas engines are not going to give you that kind of service with out a rebuild, or two. But, a half million miles on a hard working diesel is not uncommon.
on a side note: My son's 92 Cummins (I bought it new, gave it to him back in 2003) was rebuilt at 620,000 miles and during the rebuilt he added larger turbos and some other stuff, and right now it's about 450 HP, but 935 Ft/Lbs of torque!