First off if you have a goal in mind what this car will be used for, Street car race car etc? That will give you an idea of where to start? Torque is king on the street, plain and simple. Build something your going to be able to drive and enjoy,without being under the hood every other day. Do you want a 12, 11,10 second car? pick one and then build it accordingly.
I have a 71 Duster, i wanted a low 12 second car that i can drive on a regular basis. I Spoke to my engine builder and a few mopar guys here with street cars to get an idea of what they are putting up with on the street with thier rides. I came up with a different solution, i built a 426 B motor, 383 with a 440 crank. Engine builder an i sat down came up with a plan and stuck to it. the result was a motor that makes 515 Tq at 2900 RPM 552 peak and doesnt stop making tq until the shift point. So i say that was a pretty good plan. Its a very mild combo street friendly will work well with the 3.73 gears and 3400 stall converter.
Sit down make a plan With an engine builder who has been doing this for a long time, and dont worry about the 4 million opinions you will get off the internet, they are not the ones driving your car.