Hi Toolman,
I have a Binks #18 too and in its day I did some nice work with it. I love the feel and quality of that gun. I don't know how well the old #18 would do with today's materials, I suspect there would be a lot of wasted material in a huge cloud of overspray. It was really intended to deal with the heavier acrylics of years ago.
On respirators, those old acrylics were not the healthiest stuff to work with but the new Urethanes and their isocyanates are truly nasty stuff. Some people are highly sensitive to them and even a little exposure leads to long term health issues for them. When I handle iso's I suit up like I'm going to the moon. Tyvek paint suit, head sock, gloves, eye mask and respirator. Iso's can be absorbed through the skin and even your eyes.
Charcoal respirators are widely used but I haven't seen them really approved for use with iso's. They do work but I suspect the companies that make them are not willing to accept the product liability issues. With iso's being the nasty stuff they are I think the charcoal has a limited ability to absorb them so the charcoal masks have a limited life. My research indicates about 8 hours max. The charcoal is also absorbing stuff in the air even when it's not on your face so, I keep mine in a sealed zip lock bag when not in actual use. I carefully log all the time on the mask and if I think its been more heavily exposed to iso's I chuck it before the 8 hours. I'm talking about the disposable masks that don't have replaceable cartridges that you buy for around $20. I would encourage you to do your own research and arrive at your own conclusions as to how to handle these materials.
SPI Epoxy- Yes, it's a bit slow. SPI used to suggest the 30 minute induction time after mixing in the activator. They have changed that suggestion to a recommendation. I guess it gives the mixed epoxy more time to chemically activate for a stronger cure. The longer cure time gives this stuff its strength. In insurance shop work time is money and the job has to be completed quickly. Restoration work you want the best materials and job possible so time isn't as much as a factor. SPI products are aimed at restoration work more than speed.