I've used both. Right now, I'm using a 450 VS Slayer on my slant 6 and it runs fantastic. I have a 650 Brawler DP I've used on both the slant 6 and the 400 Ford engine in my 75 F250. On both the Quick fuel carburetors, my experience has been that the bleeds on top of these carburetors are much more for fine tuning and the fuel restrictors in the metering blocks are more for making larger adjustments.I get the fuel restrictors close first and then fine tune with the air bleeds. I took the 650 off the slant 6, because, while it ran great and produced more power than the 450, it was difficult to get the low speed mixture correct. I knew the 450 was a dead match, so I put it back on. I took it off the Ford, because amazingly, it wasn't enough for it and I have a Street Demon 750 three barrel on it now and it runs great.