For some background, I own a business that racks up miles. You have to erase emotion, and use logic. This vehicle will be a tool to help you support your family. Brand loyalty doesn't put food on the table. Racking up a thousand miles a week is something most people don't understand.
Quality modern vehicles can rack up 500k+ without much drama. A vehicle that gets driven everyday will rack up crazy miles no problem. My vehicles get oil every 10k, trans fluid and filter every 30k, and differential/transfer case every 60k. At every 150k they get a "mechanical douche" whether they need it or not. This entails ball joints, sway links and bushings, tie rod ends, shocks and struts, pads, rotors, calipers, ect. Basically about $1,000 in parts and an afternoon of spinning wrenches. Basically everything involved in suspension, steering, and brakes. Also factor in new rubber every year. You don't want 20's, or a bunch of bells and whistles to break. Stick with base models. Avoid anything AWD, Bluetooth enabled *** warmers, anything from Europe(sorry TDI guys, I've owned them), Subaru (seriously? They are horribly unreliable money pits), and any "economy" domestic cars.
Find a website with a good search tool. You can figure out really quickly which vehicles can rack up real miles. For vehicles that get driven 50k a year....300k is just getting broken in. A vehicle that needs to see the doctor before 250k miles is poor engineering to me.