big cams do not automatically mean hi-octane gas.
It's all about heat in the combustion chamber, and the presence or absence of hot spots. Cylinder pressure is a big part of controlling it. This does NOT automatically mean Compression Ratio, altho that's a part of it. As is elevation, inlet air temp,coolant temp and AFR.
With a given compression ratio, pressure actually drops with the later-closing intake valve, of a bigger camshaft.