When I put a low deck 400 into my 75 Dart Sport with TTI 2" headers, I had to modify one tube on the driver side because it made contact with the pitman arm. Also had very slight contact at oil pan rail with one tube, but I forget which side, and a tiny dent in the tube fixed that.
The instructions for those headers warned of this when using stock heads, or stock port location. I was using stock cast iron heads. I do believe it would have cleared everything with raised port heads or with an RB block.
As a side note, I originally had the same engine and TTI headers in a 67 b-body and there was no clearance issues with chassis or steering at all.