There are a handful of 265s around the 450-500hp mark NA (and some pretty crazy boosted builds) but it ain't cheap to do. 300-350hp NA is a walk in the park, much more than that requires some re-engineering. (Camshaft has a big unsupported section, conveniently where your dizzy & oil pump drive is - this needs addressing if your looking for power).Has Engine Masters ever done a straight-six shootout? That would be interesting too. I'd LOVE to see a no holds barred maxed-out Hemi six on the dyno.
Didn't the Aussies have a decent (ie non integrated intake manifold) head for the Ford 300?
Not really into fords so can't comment on if the 250 x flow head will go onto the 300ci block